Typhoid Fever in Uganda: Symptoms, Treatment, and Prevention of Enteric Fever

What is Typhoid Fever?

Typhoid fever, also called enteric fever, is a bacterial infection that causes fever and stomach problems. It spreads mainly through food and water that have been contaminated with harmful bacteria.

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What Causes Typhoid Fever?

The infection is caused by bacteria called Salmonella typhi and Salmonella paratyphi (types A and B).

What Are the Symptoms?

Typhoid symptoms usually develop gradually about 10 to 15 days after being infected and include:

  • Feeling cold with shivering (chills) and tiredness
  • Headache, loss of appetite, nosebleeds, back pain, and constipation
  • Stomach pain and tenderness
  • High fever over 38°C (100.4°F)
  • Confusion or drowsiness in more severe cases
  • Swollen and tender spleen
  • Slow heart rate (relative bradycardia) and sometimes a cough

If not treated, serious complications like holes in the intestines or severe bleeding in the gut can happen.

How is Typhoid Fever Diagnosed?

  • Blood tests are the most reliable way to confirm typhoid.
  • Stool tests can also help find the bacteria.
  • Rapid antibody tests may be used during outbreaks but are less accurate.
  • Widal test is not reliable on its own for diagnosis.

How is Typhoid Fever Treated?

Treatment depends on the results of tests to find the best antibiotic. Common medicines include:

  • Ciprofloxacin, taken twice daily for 10 to 14 days (doses differ for children).
  • Chloramphenicol, given every 6 hours for 10 days, can be used especially in children.
  • For severe or resistant infections, or during pregnancy, ceftriaxone injections are used.
  • Amoxicillin is an alternative for pregnant women.

Always complete the full course of treatment even if you feel better.

How Can You Prevent Typhoid Fever?

  • Detect and treat cases early to stop the spread.
  • Dispose of human waste safely.
  • Drink clean, safe water.
  • Wash hands regularly with soap, especially before eating and after using the toilet.
  • Ensure good hygiene when preparing and handling food.
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